Pharmacodynamic lincomycin nasa ne na maganin rigakafi na lincoamine, wakili ne na bacteriostatic, ƙwayoyin cuta masu mahimmanci sun haɗa da staphylococcus aureus (ciki har da ƙwayoyin penicillin-resistant), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, wasu mycoplasma (mycoplasma suis p mycoplasmasuis synovialis), leptospirosis da anaerobic kwayoyin cuta (kamar clostridium difficile, clostridium tetanus, clostridium percapsulatus da mafi yawan actinomyces). Yafi yin aiki akan sashin 50s na ribosome na kwayan cuta, kuma yana aiwatar da sakamako na kashe ƙwayoyin cuta ta hanyar hana haɓaka sarkar peptide kuma yana shafar haɗin furotin.
Shayarwa ta kasance mai sauri bayan allurar intramuscularly, tare da allurar intramuscular guda ɗaya na 11mg/kg a cikin aladu da ƙimar jini mafi girma na 6.25μg/ml. Adadin daurin furotin na plasma ya kasance 57% - 72%. An rarraba shi sosai a cikin vivo, tare da bayyananniyar girman rarraba 2.8 l / kg a cikin aladu. Ana rarraba shi sosai a cikin ruwaye da kyallen jikin mutum daban-daban (ciki har da kashi), wanda a cikinsa yawan hanta da koda shine mafi girma, kuma yawan ƙwayar nama ya ninka sau da yawa fiye da na jini a lokaci guda. Yana iya shiga cikin mahaifa, amma ba shi da sauƙi don shiga shingen jini-kwakwalwa, kuma yana da wuya a kai ga tasiri mai tasiri na miyagun ƙwayoyi a cikin ruwan cerebrospinal lokacin da kumburi ya faru. Ana iya rarraba shi zuwa madara, kuma maida hankali a cikin madara daidai yake da na plasma. Wani ɓangare na miyagun ƙwayoyi yana daidaitawa a cikin hanta, kuma nau'in miyagun ƙwayoyi da metabolites suna fitar da su ta hanyar bile, fitsari da madara. Za'a iya jinkirta fitar da stool na kwanaki da yawa, don haka yana da tasirin hanawa akan ƙwayoyin cuta na hanji.
1. Lokacin da aka haɗe shi da gentamicin, yana da tasiri mai tasiri akan kwayoyin gram-tabbatacce irin su staphylococcus da streptococcus.
2. Lokacin da aka haɗa tare da aminoglycosides da maganin rigakafi na polypeptide, yana iya haɓaka tasirin toshewa akan haɗin neuromuscular. Haɗe tare da erythromycin yana da tasirin ƙin yarda, saboda wurin aiki iri ɗaya ne, kuma erythromycin yana da alaƙa mai ƙarfi zuwa sashin 50s na ribosomes na kwayan cuta fiye da wannan samfur.
3. Kada a hada shi da maganin zawo wanda ke hana peristalsis na hanji kuma yana dauke da farin yumbu. 4. Akwai rashin jituwa da kanamycin, neomycin, da dai sauransu.
Lincoamine maganin rigakafi. Don kamuwa da ƙwayoyin cuta na gram-tabbatacce, ana iya amfani da su don treponemosis da mycoplasma da sauran cututtuka.
Intramuscularly allura: kashi daya, 0.0165 ~ 0.033ml da 1kg nauyi na dawakai da shanu, 0.033ml na tumaki da alade, sau ɗaya a rana; 0.033ml na karnuka da kuliyoyi, sau biyu a rana, don kwanaki 3 zuwa 5.
Allurar cikin tsoka na iya haifar da gudawa mai wucewa ko kuma tausasawa. Ko da yake ba kasafai ba, ya kamata a dauki matakan da suka dace don hana bushewa idan sun faru.
