10% Iron Dextran Allurar

Pharmacodynamic iron shine babban bangaren haemoglobin da myoglobin. Haemoglobin shine babban mai ɗaukar iskar oxygen a cikin jajayen ƙwayoyin jini. Myoglobin shine inda ƙwayoyin tsoka ke adana iskar oxygen don taimakawa wajen samar da shi ga tsokoki yayin motsa jiki. Yawancin enzymes da abubuwan da ke cikin zagayowar tricarboxylic acid sun ƙunshi ƙarfe ko aiki kawai a gaban ƙarfe. Sabili da haka, ban da haɓakar haemoglobin mai sauri, alamun da ke da alaƙa da ƙarancin ƙarfe na nama da raguwar ayyukan enzymes masu ɗauke da baƙin ƙarfe, kamar haɓakar haɓakar haɓakar haɓaka, halayen halayen halayen, da raunin jiki, ana iya gyara su a hankali bayan ƙarin ƙarfe mai aiki a cikin dabbobin da ba su da ƙarfe. Iron Pharmacokinetic don allura yana ɗaukar sauri fiye da baƙin ƙarfe na baki; bayan allurar iron dextran cikin tsoka, yawan jinin ya kai kololuwar sa a sa'o'i 24-48, kuma kwayoyinsa sun fi girma. An shafe ta da tasoshin lymphatic sannan kuma su shiga cikin jini, kuma jinin jini ya karu a hankali; bayan shigar da allurar ciki ko intramuscular a cikin jini, yana da phagocytic kuma ya bazu zuwa ƙarfe da dextran ta tsarin sel phagocytic mononuclear. Bayan sha, ions baƙin ƙarfe suna oxidized zuwa ferric ions ta ceruloplasmin a cikin jini, sa'an nan kuma daura zuwa transferrin receptors, shigar da sel a cikin nau'i na pinocytosis ga hematopoietic Kwayoyin, ko tara a cikin nau'i na ferritin ko hemosiderin a cikin hanta, saifa, kasusuwa kasusuwa da sauran mononuclear phagocytic cell tsarin. Adadin daurin furotin yana da yawa a cikin haemoglobin, amma ƙarancin myoglobin, enzymes da sunadarai masu jigilar baƙin ƙarfe, da ƙarancin ferritin ko hemosiderin.