Pharmacodynamics flufenicol babban maganin rigakafi ne.
Na aminools, bacteriosuppressor, kuma yana aiki ta hanyar ɗaure tare da ribosome 50s subunit don hana haɗin sunadarai na ƙwayoyin cuta. Yana da aikin kashe kwayoyin cuta mai ƙarfi akan ƙwayoyin cuta iri-iri na gram-tabbatacce da gram-korau. Pasteurella hemolyticus, pasteurella multocida da actinobacillus suis pleuropneumoniae sun kasance masu kula da flufenicol sosai. A cikin vitro, aikin antimicrobial na flufenicol akan ƙwayoyin cuta da yawa yana kama da ko ya fi ƙarfi fiye da na sulfenicol, da kuma wasu ƙwayoyin cuta waɗanda ke jure wa aminools saboda acetylation, kamar escherichia coli da klebsiella pneumoniae, na iya har yanzu suna kula da flufenicol.
An fi amfani da shi don cututtukan ƙwayoyin cuta na alade, kaji da kifi waɗanda ke haifar da ƙwayoyin cuta masu mahimmanci, kamar cututtukan numfashi na shanu da aladu da pasteurella hemolyticus, pasteurella multocida da actinobacillus pleuropneumoniae ke haifarwa. Typhoid da paratyphoid da ke haifar da salmonella, kwalara, kaji, dysentery fari kaza, colibacillosis, da dai sauransu; kifi pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis da sauran kwayoyin cuta lalacewa ta hanyar kifi bakteriya septicemia, enteritis, erythroderma da kuma nan da nan.
Pharmacokinetics flufenicol yana da sauri cikin kulawa ta hanyar gudanarwa na ciki, kuma ana iya kaiwa ga maida hankali a cikin jini bayan kimanin awa 1, kuma ana iya kaiwa ga mafi girman matakin jini a cikin sa'o'i 1 zuwa 3. A bioavailability ne fiye da 80%. Flufenicol yana yaduwa a cikin dabbobi kuma yana iya ketare shingen kwakwalwar jini. Ana fitar da shi ne musamman a cikin fitsari a sifarsa ta asali kuma da kadan a cikin najasa.
1. Macrolides da lincoamines suna da manufa iri ɗaya da wannan samfurin, an haɗa su tare da subunit na ribosome 50s na kwayan cuta, kuma suna iya haifar da sakamako na gaba idan an haɗa su.
2. Yana iya adawa da ayyukan ƙwayoyin cuta na penicillins ko aminoglycosides, amma ba a tabbatar da hakan a cikin dabbobi ba.
Magungunan maganin rigakafi na Amidoalcohol, mai matukar damuwa ga Pasteurella hemolyticus, Pasteurella multocida da actinobacillus pleuropneumoniae, ana amfani da su don cututtukan Pasteurella da Escherichia coli.
Intramuscular allura: daya kashi, da 1kg nauyi jiki, 0.2ml na kaza, 0.15 ~ 0.2ml na tumaki da alade, 0.075 ~ 0.1ml na dawakai da shanu. Sau ɗaya kowane awa 48, sau biyu a jere. Kifi 0.005 zuwa 0.01ml sau ɗaya a rana.
1. Wannan samfurin yana da takamaiman tasirin rigakafi lokacin amfani da shi sama da adadin da aka ba da shawarar.
2. Yana da guba na tayin, kuma yakamata a yi amfani da shi tare da taka tsantsan yayin daukar ciki da shayarwa.
1. An haramta lokacin kwanciya kaji.
2. Ya kamata a hana dabbobi masu tsananin ƙarancin rigakafi ko lokacin rigakafin.
3. Dabbobin da ke da karancin koda ya kamata a rage su da kyau ko kuma a tsawaita tazarar lokacin gudanarwa.
